ABSTRACT: University teaching work, whose goal is to contribute to society with high-quality professionals, requires a training process in which learning with effectiveness and autonomy is a central axis in any educational process. What seems like a natural goal to achieve does not always occur spontaneously and successfully. For this reason, teacher training is an opportunity to mediate our students, following intentionally and meaningfully inclusive teaching to promote autonomy in university classes. This paper presents the meaning of mediating teaching from the self-regulation of learning perspective, its relevance, implications, and challenges for autonomous and inclusive learning in university practices. Moreover, we address the importance of promoting an effective involvement of teachers in teaching strategies of self-regulation of learning to their students, which will be helpful to their lives beyond the university classrooms.

RESUMEN: El trabajo docente universitario, cuya meta es contribuir a la sociedad con profesionales de alta calidad, requiere de un proceso formador en que el aprender con efectividad y autonomía es un eje central en todo proceso educativo. Lo que parece una meta natural a alcanzar, no siempre se produce espontáneamente y de manera exitosa. Por ello, el acompañamiento docente es una oportunidad para mediar a la comunidad estudiantil intencionado una docencia inclusiva de manera significativa que aspira a promover el proceso de autonomía desde el aula universitaria. En este artículo presentamos el significado de la docencia mediadora desde la autorregulación del aprendizaje, su relevancia, implicaciones y desafíos para el aprendizaje autónomo e inclusivo en la práctica educativa universitaria y la importancia de promover una implicación efectiva de los docentes en la enseñanza de estrategias de autorregulación del aprendizaje a sus estudiantes, las cuales trascenderán las aulas universitarias proyectándose hacia la propia vida.

Abstract Ernesto Guevara is a well-known character. Before he participated in various revolutions throughout Latin America, he dedicated his early life and daily work to medicine, his profession, some of which he performed in Hospital General de México.

ABSTRACT Objective Radium-223(223Ra) is indicated for patients (p) with metastatic castration resistant prostate cancer (mCRCP). Objectives The aim of this study was to evaluate the role of baseline clinical variables associated with overall survival (OS) and toxicity of 223Ra. Its purpose was to identify the factors that can predict a better response to treatment and provide information regarding the most appropriate time for the application of 223Ra. Materials and Methods Prospective study in 40p with mCRPC treated with 223Ra. End points were OS, progression-free survival and time to progression. The follow-up parameters were: doses received, hemoglobin (Hb), absolute neutrophil count (ANC), platelet count (PC), prostate specific antigen (PSA), alkaline phosphatase (ALP), Visual Analogue Scale for pain, Eastern Cooperative Oncology Group (ECOG) and WHO’s Cancer Pain Ladder. The use of other treatments was also evaluated. Results Median OS was 17.1 months(mo) (CI95%6.5-27.7); 26/40p received complete treatment of 223Ra, without reaching a median OS and 14p received incomplete treatment with a median OS 13.6mo(CI95%1.6-25.6). Median follow-up was 11.2mo (range:1.3-45.2). The univariate analysis showed that factors as VAS, ECOG, Hb and ALP values were independently associated with OS. First line treatment with 223Ra was started in 11/40p, while 19p had been heavily pre-treated and 13p received concomitant treatment. Conclusions 223Ra therapy require an adequate selection of patients to obtain the greatest clinical benefit. Low basal Hb, hight basal ALP, bone marrow involvement and an altered ECOG were the main factors that decreased OS in our patients. 223Ra should be considered relatively early in the course of treatment.

Abstract Background: Frailty syndrome is a state of greater vulnerability manifesting with functional impairment, dependence, and mortality. For its study, it has been used the Fried model. The prevalence found in the same hospital in studies of 1998 and 2015 was 16.5% and 31.2%. We propose to determine the current prevalence using the model proposed by Fried. Materials and methods: A descriptive, cross-sectional, and retrospective study was performed in the Hospital General de México, with 109 participants above 70 years old. Demographic, antrophometric, comorbidities, and functionality data were obtained. Modified Fried criteria were used for classification. The index of Katz and Lawton and Brody was used to assess the basic and instrumental activities of daily living. For statistical analysis, the software SPSS-24 was used. Results: The mean age was 80 years and standard deviation ± 5.63, 74.1% (83 patients) were female. Comorbidities were registered in 86.6%. About 92% obtained Katz A classification, 5.3% Katz B, and 1.7% Katz C. In the Lawton and Brody index, 86.6% were found to be independent. About 14.3% were classified as non-frail, 50% as pre-frail, and 35.7% as frailty. Conclusions: We determined a prevalence of 35.7%, being 28% greater than the one reported by Fried et al., and 20% and 6% greater than the reported in the studies of 1998 and 2015 in the same hospital. Given that it is possible to recover from fragile to pre-frail, this knowledge will serve to design strategies for the benefit of the patients.

Abstract: Introduction: Mycotic infections due to Aspergillus spp, are the main mycotic associated infections in liver transplant patients, with mortality rates up to 90% of the cases. Almost 50% of patients will de velop an infection during the first months after transplantation, of which 10% are associated with op portunistic agents. Objective: To describe the diagnosis and management of an Invasive Pulmonary Aspergillosis (IPA) episode in a liver transplant patient. Case report: 11-months-old patient with liver transplant due to a biliary atresia who developed severe pneumonia associated with mechanical ventilation. The bronchoalveolar lavage showed high levels of galactomannan and positive culture for Aspergillus fumigatus leading to an IPA diagnosis. This episode was treated with antifungal with a favorable outcome. Conclusion: The IPA is an opportunistic infection in liver transplant patients, with high mortality rates, that must be suspected in this group of patients since an early diagnosis and treatment reduce mortality.

Resumen: Introducción: Las infecciones por Aspergillus spp son la principal infección micótica por hongos en pacientes con trasplante hepático, con una mortalidad reportada de hasta un 90% de los casos. En los pacientes trasplantados de hígado se espera que hasta un 50% desarrollen un episodio infeccioso en sus primeros meses postrasplante, de los cuales un 10% se asocian con agentes oportunistas. Ob jetivo: Describir el diagnóstico y manejo de un episodio de Aspergilosis Pulmonar Invasora (API) en una paciente con un trasplante hepático Caso clínico: Paciente de 11 meses de vida, con trasplante hepático secundario a atresia de vías biliares. En el periodo post-trasplante inmediato evolucionó con una neumonía grave asociada a ventilación mecánica. El lavado broncoalveolar presentó niveles altos de galactomanano y cultivo positivo para Aspergillus fumigatus, diagnosticándose una API. Este episodio se trató con un esquema de antifúngico con un resultado clínico favorable. Conclusión: La API es una infección oportunista en pacientes con trasplante hepático, que debe ser sospechada en este grupo de pacientes, ya que el diagnóstico y tratamiento oportuno impacta directamente en la resolución de la infección por Aspergillus fumigatus.

Abstract: Objective: To analyze the transcription pattern of neuropeptides in the ontogeny of a malaria vector, the mosquito Anopheles albimanus. Materials and methods: The transcription pattern of Crustacean CardioActive peptide (CCAP), corazonin, Ecdysis Triggering Hormone (ETH), allatostatin-A, orcokinin, Insulin Like Peptide 2 (ILP2), Insulin Like Peptide 5 (ILP5) and bursicon was evaluated using qPCR on larvae (1st - 4th instar), pupae and adult mosquitoes. Results: Unlike in other insects, transcripts of CCAP (70.8%), ETH (60.2%) and corazonin (76.5%) were expressed in 4th instar larvae, probably because these three neuropeptides are associated with the beginning of ecdysis. The neuropeptide ILP2 showed higher transcription levels in other stages and orcokinin decreased during the development of the mosquito. Conclusion: The CCAP, corazonin and ETH neuropeptides are potential targets for the design of control strategies aimed at disrupting An. albiamnus larval development.

Resumen: Objetivo: Describir la expresión de neuropéptidos durante la ontogenia del mosquito vector de la malaria Anopheles albimanus. Material y métodos: Se midió la expresión de CCAP, corazonina, ETH, allatostatina, orcokinina, ILP2, ILP5 y bursicon en larvas de primer (2mm), segundo (4mm), tercer (5mm) y cuarto (6mm) estadio, pupas y mosquitos adultos, mediante qPCR. Resultados. A diferencia de otros insectos en donde, CCAP, corazonina y ETH se expresan principalmente en estadios pupales, en An. albimanus se expresaron mayoritariamente en larvas de cuarto estadio, CCAP tuvo 70.8% de expresión relativa, corazonina 76.5% y ETH 60.2%. ILP2 fue el neuropéptido que más se expresó en el primer, segundo y tercer estadio y orcokinina disminuyó durante el desarrollo del mosquito. Conclusión. Los péptidos estudiados se expresaron en todos los estadios de desarrollo del mosquito. Sin embargo, su expresión varió en cada uno de ellos. Los neuropéptidos CCAP, corazonina y ETH, que son esenciales para la transformación de lavas a pupas, pueden ser blancos potenciales para el diseño de estrategias de control dirigidas a interrumpir el desarrollo larvario de An. albimanus.

Abstract: Objective: To analyze the transcription pattern of neuropeptides in the ontogeny of a malaria vector, the mosquito Anopheles albimanus. Materials and methods: The transcription pattern of Crustacean CardioActive peptide (CCAP), corazonin, Ecdysis Triggering Hormone (ETH), allatostatin-A, orcokinin, Insulin Like Peptide 2 (ILP2), Insulin Like Peptide 5 (ILP5) and bursicon was evaluated using qPCR on larvae (1st - 4th instar), pupae and adult mosquitoes. Results: Unlike in other insects, transcripts of CCAP (70.8%), ETH (60.2%) and corazonin (76.5%) were expressed in 4th instar larvae, probably because these three neuropeptides are associated with the beginning of ecdysis. The neuropeptide ILP2 showed higher transcription levels in other stages and orcokinin decreased during the development of the mosquito. Conclusion: The CCAP, corazonin and ETH neuropeptides are potential targets for the design of control strategies aimed at disrupting An. albiamnus larval development.

Resumen: Objetivo: Describir la expresión de neuropéptidos durante la ontogenia del mosquito vector de la malaria Anopheles albimanus. Material y métodos: Se midió la expresión de CCAP, corazonina, ETH, allatostatina, orcokinina, ILP2, ILP5 y bursicon en larvas de primer (2mm), segundo (4mm), tercer (5mm) y cuarto (6mm) estadio, pupas y mosquitos adultos, mediante qPCR. Resultados. A diferencia de otros insectos en donde, CCAP, corazonina y ETH se expresan principalmente en estadios pupales, en An. albimanus se expresaron mayoritariamente en larvas de cuarto estadio, CCAP tuvo 70.8% de expresión relativa, corazonina 76.5% y ETH 60.2%. ILP2 fue el neuropéptido que más se expresó en el primer, segundo y tercer estadio y orcokinina disminuyó durante el desarrollo del mosquito. Conclusión. Los péptidos estudiados se expresaron en todos los estadios de desarrollo del mosquito. Sin embargo, su expresión varió en cada uno de ellos. Los neuropéptidos CCAP, corazonina y ETH, que son esenciales para la transformación de lavas a pupas, pueden ser blancos potenciales para el diseño de estrategias de control dirigidas a interrumpir el desarrollo larvario de An. albimanus.

The present research was carried out in three enterprises of food production in the province of Cienfuegos. It was pursued the objective of identifying factors with higher incidence in labor accidents in such companies. The accidents in the last five years in such organizations were taken as reference in the research. It was designed and implemented a procedure for the analysis of labor accidents, obtaining a regression model which allowed explaining the causes of such accidents, based on a set of explanatory variables obtained through the use of interviews, checklists, direct observations, questionnaires, Delphi´s Method. From the point of view of mathematical statistical model, it is used the Logistic Regression Model, Poisson Regression Model, Negative Binomial Regression Model and factorial analysis. The factors with higher incidence in the accidents were the satisfaction regarding working conditions and management of occupational safety and health.

La presente investigación se realizó en tres entidades de la producción de alimentos de la provincia de Cienfuegos. Se identificaron los factores de mayor incidencia en los accidentes laborales ocurridos en las empresas estudiadas. Para ello se tomaron como referencia los accidentes ocurridos en los últimos cinco años en dichas organizaciones. Se diseñó y aplicó un procedimiento para el análisis de la accidentalidad laboral, en el que se obtuvo un modelo de regresión que permitió explicar las causas de la accidentalidad laboral. Este procedimiento está basado en un conjunto de variables explicativas obtenidas mediante la utilización de entrevistas, listas de chequeo, observaciones directas, cuestionarios, Método de Delphi. Desde el punto de vista estadístico matemático se utiliza el modelo de Regresión Logística, Regresión de Poisson y la Regresión Binomial Negativa, así como el análisis factorial.

Objective. To identify studies on quality of health care in the IMSS. Materials and methods. A bibliometric, descriptive cross-sectional and retrospective study was conducted, from 1992 to 2011. Results. We identified 881 research studies related to the issue of quality (CI95% 10.6-12.0) of 7 762 studies presented at the annual research meetings. 10 521 articles were published in this period of time and only 946 (CI95% 8.4-9.5) were linked to the issue of quality. Conclusions. The results of this study allowed us to identify the interest about research on quality. Further research is needed to establish what has been the impact on the improvement of quality in health care.

Objetivo. Identificar las investigaciones sobre calidad de la atención en el IMSS. Material y métodos. Estudio bibliométrico, transversal, retrospectivo y descriptivo, sobre las publicaciones del IMSS de 1992 a 2011. Resultados. Se identificaron 881 investigaciones sobre calidad de la atención (11% IC95% 10.6-12.0) de 7 762 trabajos. Se publicaron 946 artículos (8.9% IC95% 8.4-9.5) relacionados con la calidad. Conclusiones. Se identificó interés en realizar investigación sobre calidad del servicio. Habrá que establecer cuál ha sido el impacto en la mejora de la atención, y su contribución a la toma de decisiones en materia de salud.

Objective. To identify studies on quality of health care in the IMSS. Materials and methods. A bibliometric, descriptive cross-sectional and retrospective study was conducted, from 1992 to 2011. Results. We identified 881 research studies related to the issue of quality (CI95% 10.6-12.0) of 7 762 studies presented at the annual research meetings. 10 521 articles were published in this period of time and only 946 (CI95% 8.4-9.5) were linked to the issue of quality. Conclusions. The results of this study allowed us to identify the interest about research on quality. Further research is needed to establish what has been the impact on the improvement of quality in health care.

Objetivo. Identificar las investigaciones sobre calidad de la atención en el IMSS. Material y métodos. Estudio bibliométrico, transversal, retrospectivo y descriptivo, sobre las publicaciones del IMSS de 1992 a 2011. Resultados. Se identificaron 881 investigaciones sobre calidad de la atención (11% IC95% 10.6-12.0) de 7 762 trabajos. Se publicaron 946 artículos (8.9% IC95% 8.4-9.5) relacionados con la calidad. Conclusiones. Se identificó interés en realizar investigación sobre calidad del servicio. Habrá que establecer cuál ha sido el impacto en la mejora de la atención, y su contribución a la toma de decisiones en materia de salud.